Evolutionary Coupling Analysis
Predicted and experimental contacts
Secondary structure from ECs
EC score distribution and threshold
Top ECs
Rank |
Residue 1 |
Amino acid 1 |
Residue 2 |
Amino acid 2 |
EC score |
1 |
579 |
Y |
583 |
N |
0.62 |
2 |
609 |
K |
613 |
L |
0.57 |
3 |
563 |
V |
567 |
Y |
0.55 |
4 |
580 |
Q |
584 |
D |
0.54 |
5 |
559 |
N |
563 |
V |
0.52 |
6 |
558 |
N |
562 |
E |
0.49 |
7 |
571 |
N |
575 |
K |
0.48 |
8 |
572 |
V |
576 |
A |
0.48 |
9 |
568 |
Q |
573 |
L |
0.47 |
10 |
512 |
F |
516 |
R |
0.47 |
11 |
570 |
K |
575 |
K |
0.46 |
12 |
478 |
N |
482 |
M |
0.46 |
13 |
551 |
E |
555 |
N |
0.46 |
14 |
559 |
N |
564 |
R |
0.45 |
15 |
569 |
R |
573 |
L |
0.45 |
16 |
515 |
K |
519 |
R |
0.45 |
17 |
522 |
E |
526 |
K |
0.44 |
18 |
523 |
E |
527 |
N |
0.43 |
19 |
568 |
Q |
572 |
V |
0.43 |
20 |
552 |
G |
556 |
A |
0.42 |
21 |
520 |
E |
524 |
Q |
0.42 |
22 |
514 |
S |
518 |
R |
0.42 |
23 |
575 |
K |
579 |
Y |
0.41 |
24 |
512 |
F |
517 |
R |
0.41 |
25 |
551 |
E |
556 |
A |
0.41 |
26 |
616 |
G |
620 |
D |
0.41 |
27 |
578 |
R |
582 |
E |
0.41 |
28 |
627 |
N |
631 |
E |
0.40 |
29 |
526 |
K |
537 |
E |
0.40 |
30 |
561 |
S |
566 |
R |
0.40 |
31 |
530 |
I |
534 |
L |
0.40 |
32 |
557 |
N |
567 |
Y |
0.39 |
33 |
612 |
A |
618 |
E |
0.39 |
34 |
587 |
D |
591 |
E |
0.39 |
35 |
486 |
N |
493 |
V |
0.39 |
36 |
560 |
I |
564 |
R |
0.38 |
37 |
525 |
L |
530 |
I |
0.38 |
38 |
542 |
Q |
546 |
S |
0.38 |
39 |
532 |
E |
537 |
E |
0.38 |
40 |
571 |
N |
576 |
A |
0.38 |
41 |
513 |
N |
517 |
R |
0.38 |
42 |
534 |
L |
539 |
T |
0.38 |
43 |
642 |
M |
646 |
R |
0.38 |
44 |
500 |
N |
504 |
L |
0.38 |
45 |
472 |
L |
476 |
E |
0.37 |
46 |
576 |
A |
580 |
Q |
0.37 |
47 |
569 |
R |
574 |
E |
0.37 |
48 |
475 |
V |
479 |
L |
0.37 |
49 |
550 |
I |
554 |
M |
0.37 |
50 |
530 |
I |
536 |
R |
0.36 |
51 |
550 |
I |
555 |
N |
0.36 |
52 |
497 |
K |
501 |
R |
0.36 |
53 |
643 |
N |
647 |
L |
0.36 |
54 |
573 |
L |
577 |
K |
0.36 |
55 |
530 |
I |
537 |
E |
0.36 |
56 |
561 |
S |
567 |
Y |
0.36 |
57 |
557 |
N |
561 |
S |
0.36 |
58 |
623 |
Q |
627 |
N |
0.35 |
59 |
538 |
Q |
542 |
Q |
0.35 |
60 |
525 |
L |
529 |
K |
0.35 |
61 |
489 |
A |
493 |
V |
0.35 |
62 |
557 |
N |
565 |
E |
0.35 |
63 |
557 |
N |
564 |
R |
0.34 |
64 |
521 |
R |
527 |
N |
0.34 |
65 |
548 |
Q |
552 |
G |
0.34 |
66 |
569 |
R |
575 |
K |
0.34 |
67 |
524 |
Q |
528 |
R |
0.34 |
68 |
534 |
L |
538 |
Q |
0.34 |
69 |
550 |
I |
556 |
A |
0.34 |
70 |
492 |
K |
496 |
L |
0.34 |
71 |
579 |
Y |
584 |
D |
0.34 |
72 |
531 |
E |
535 |
M |
0.34 |
73 |
527 |
N |
531 |
E |
0.34 |
74 |
557 |
N |
566 |
R |
0.33 |
75 |
529 |
K |
533 |
K |
0.33 |
76 |
495 |
E |
499 |
L |
0.33 |
77 |
572 |
V |
577 |
K |
0.33 |
78 |
588 |
D |
592 |
L |
0.33 |
79 |
584 |
D |
588 |
D |
0.33 |
80 |
486 |
N |
492 |
K |
0.33 |
81 |
569 |
R |
576 |
A |
0.33 |
82 |
594 |
I |
601 |
I |
0.33 |
83 |
483 |
K |
487 |
K |
0.33 |
84 |
595 |
D |
618 |
E |
0.33 |
85 |
490 |
D |
496 |
L |
0.32 |
86 |
562 |
E |
566 |
R |
0.32 |
87 |
610 |
K |
614 |
T |
0.32 |
88 |
577 |
K |
581 |
F |
0.32 |
89 |
485 |
Q |
492 |
K |
0.32 |
90 |
475 |
V |
483 |
K |
0.32 |
91 |
592 |
L |
596 |
R |
0.32 |
92 |
585 |
E |
590 |
M |
0.32 |
93 |
536 |
R |
540 |
S |
0.32 |
94 |
570 |
K |
574 |
E |
0.32 |
95 |
575 |
K |
580 |
Q |
0.32 |
96 |
523 |
E |
530 |
I |
0.32 |
97 |
604 |
V |
608 |
L |
0.32 |
98 |
558 |
N |
564 |
R |
0.32 |
99 |
525 |
L |
533 |
K |
0.32 |
100 |
488 |
V |
492 |
K |
0.31 |
101 |
556 |
A |
562 |
E |
0.31 |
102 |
631 |
E |
635 |
D |
0.31 |
103 |
481 |
L |
485 |
Q |
0.31 |
104 |
532 |
E |
539 |
T |
0.31 |
105 |
400 |
D |
471 |
Q |
0.31 |
106 |
594 |
I |
612 |
A |
0.31 |
107 |
519 |
R |
523 |
E |
0.31 |
108 |
537 |
E |
541 |
Q |
0.30 |
109 |
606 |
N |
610 |
K |
0.30 |
110 |
495 |
E |
502 |
S |
0.30 |
111 |
523 |
E |
529 |
K |
0.30 |
112 |
474 |
N |
478 |
N |
0.30 |
113 |
607 |
R |
611 |
M |
0.30 |
114 |
502 |
S |
506 |
V |
0.30 |
115 |
545 |
Q |
549 |
R |
0.30 |
116 |
547 |
T |
551 |
E |
0.30 |
117 |
476 |
E |
483 |
K |
0.30 |
118 |
541 |
Q |
545 |
Q |
0.30 |
119 |
483 |
K |
491 |
E |
0.30 |
120 |
517 |
R |
521 |
R |
0.30 |
121 |
535 |
M |
539 |
T |
0.29 |
122 |
559 |
N |
568 |
Q |
0.29 |
123 |
556 |
A |
560 |
I |
0.29 |
124 |
567 |
Y |
571 |
N |
0.29 |
125 |
483 |
K |
492 |
K |
0.29 |
126 |
489 |
A |
495 |
E |
0.29 |
127 |
561 |
S |
565 |
E |
0.29 |
128 |
617 |
K |
621 |
S |
0.29 |
129 |
527 |
N |
538 |
Q |
0.29 |
130 |
572 |
V |
579 |
Y |
0.29 |
131 |
624 |
K |
628 |
N |
0.29 |
132 |
474 |
N |
489 |
A |
0.29 |
133 |
557 |
N |
562 |
E |
0.29 |
134 |
479 |
L |
486 |
N |
0.29 |
135 |
521 |
R |
531 |
E |
0.29 |
136 |
623 |
Q |
629 |
I |
0.29 |
137 |
640 |
L |
644 |
T |
0.29 |
138 |
524 |
Q |
535 |
M |
0.29 |
139 |
607 |
R |
618 |
E |
0.28 |
140 |
573 |
L |
581 |
F |
0.28 |
141 |
493 |
V |
499 |
L |
0.28 |
142 |
578 |
R |
583 |
N |
0.28 |
143 |
479 |
L |
483 |
K |
0.28 |
144 |
560 |
I |
565 |
E |
0.28 |
145 |
601 |
I |
608 |
L |
0.28 |
146 |
632 |
S |
643 |
N |
0.27 |
147 |
475 |
V |
482 |
M |
0.27 |
148 |
532 |
E |
536 |
R |
0.27 |
149 |
493 |
V |
497 |
K |
0.27 |
150 |
506 |
V |
511 |
P |
0.27 |
151 |
516 |
R |
521 |
R |
0.27 |
152 |
646 |
R |
651 |
R |
0.27 |
153 |
560 |
I |
567 |
Y |
0.27 |
154 |
517 |
R |
522 |
E |
0.27 |
155 |
556 |
A |
563 |
V |
0.27 |
156 |
570 |
K |
576 |
A |
0.27 |
157 |
555 |
N |
559 |
N |
0.27 |
158 |
613 |
L |
621 |
S |
0.27 |
159 |
521 |
R |
525 |
L |
0.27 |
160 |
597 |
N |
612 |
A |
0.27 |
161 |
568 |
Q |
578 |
R |
0.27 |
162 |
566 |
R |
577 |
K |
0.27 |
163 |
485 |
Q |
489 |
A |
0.27 |
164 |
615 |
T |
620 |
D |
0.26 |
165 |
493 |
V |
501 |
R |
0.26 |
166 |
528 |
R |
537 |
E |
0.26 |
167 |
475 |
V |
490 |
D |
0.26 |
168 |
521 |
R |
526 |
K |
0.26 |
169 |
530 |
I |
538 |
Q |
0.26 |
170 |
520 |
E |
528 |
R |
0.26 |
171 |
519 |
R |
525 |
L |
0.26 |
172 |
535 |
M |
540 |
S |
0.26 |
173 |
553 |
A |
557 |
N |
0.26 |
174 |
518 |
R |
522 |
E |
0.26 |
175 |
615 |
T |
619 |
L |
0.26 |
176 |
533 |
K |
539 |
T |
0.26 |
177 |
599 |
D |
618 |
E |
0.26 |
178 |
624 |
K |
631 |
E |
0.26 |
179 |
594 |
I |
618 |
E |
0.26 |
180 |
583 |
N |
590 |
M |
0.25 |
181 |
490 |
D |
494 |
A |
0.25 |
182 |
477 |
G |
481 |
L |
0.25 |
183 |
556 |
A |
565 |
E |
0.25 |
184 |
616 |
G |
623 |
Q |
0.25 |
185 |
582 |
E |
586 |
E |
0.25 |
186 |
534 |
L |
546 |
S |
0.25 |
187 |
582 |
E |
590 |
M |
0.25 |
188 |
573 |
L |
579 |
Y |
0.25 |
189 |
474 |
N |
487 |
K |
0.25 |
190 |
491 |
E |
495 |
E |
0.25 |
191 |
473 |
N |
478 |
N |
0.25 |
192 |
611 |
M |
615 |
T |
0.25 |
193 |
550 |
I |
559 |
N |
0.25 |
194 |
589 |
E |
593 |
E |
0.25 |
195 |
557 |
N |
563 |
V |
0.25 |
196 |
553 |
A |
566 |
R |
0.25 |
197 |
477 |
G |
483 |
K |
0.25 |
198 |
516 |
R |
520 |
E |
0.25 |
199 |
637 |
D |
641 |
H |
0.25 |
200 |
534 |
L |
540 |
S |
0.24 |
201 |
620 |
D |
624 |
K |
0.24 |
202 |
582 |
E |
587 |
D |
0.24 |
203 |
554 |
M |
565 |
E |
0.24 |
204 |
502 |
S |
508 |
V |
0.24 |
205 |
491 |
E |
501 |
R |
0.24 |
206 |
554 |
M |
560 |
I |
0.24 |
207 |
537 |
E |
544 |
S |
0.24 |
Alignment robustness analysis
First most common residue correlation
Second most common residue correlation